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Selected Publications Dr. Nicolas Granger

We are pleased to present below recent publications from our neurologist Dr. Nicolas Granger. Both our neurology clinicians are research active, contributing to the literature with original research and collaborative projects in the UK, but also world-wide. Dr Nicolas Granger is receiving funding at Cave Vet Specialist from the International Spinal Research Trust. Some of Nicolas’s publications are free to read online and appear in red below. To view the rest, you can use the medical search engine PubMed. Their research is published in peer-reviewed journals and conforms to UK ethical guidelines. If you would like to know more about particular aspects of these, please do not hesitate to get in touch.

Dr Nicolas Granger DVM PhD DipECVN FHEA MRCVS

Suspected air embolism through the thoracic ventral internal vertebral venous plexus during hemilaminectomy in dogs.
Mortera-Balsa V, van Oostrom H, Yeamans C, Gutierrez-Quintana R, Penderis J, Granger N.
J Small Anim Pract. 2017 Apr 10. doi: 10.1111/jsap.12665. [Epub ahead of print]

Prognostic Factors Associated with Recovery of Ambulation and Urinary Continence in Dogs with Acute Lumbosacral Spinal Cord Injury.
Shaw TA, De Risio L, Laws EJ, Rose JH, Harcourt-Brown TR, Granger N.
J Vet Intern Med. 2017 May;31(3):825-831

Targeting translational successes through CANSORT-SCI: using pet dogs to identify effective treatments for spinal cord injury.
Moore SA, Granger N, Olby N, Spitzbarth I, Jeffery ND, Tipold A, Nout-Lomas YS, da Costa R, Stein V, Noble-Haeusslein L, Blight AR, Grossman R, Basso DM Ed D Pt, Levine JM.
J Neurotrauma. 2017 Feb 23.

The effectiveness of manual bladder expression in paraplegic dogs.
Carwardine D, Rose JH, Harcourt-Brown TR, Granger N.
Am J Vet Res. 2017 Jan;78(1):107-112.

Pathophysiology, clinical significance and management of neurogenic lower urinary tract dysfunction caused by supra-sacral spinal cord injury.
Hu HZ, Granger N, Jeffery ND
J Vet Intern Med. 2016 Sep;30(5):1575-1588.

Degenerative Encephalopathy in Nova Scotia Duck Tolling Retrievers Presenting with a Rapid Eye Movement Sleep Behavior Disorder.
Barker EN, Dawson LJ, Rose JH, Van Meervenne S, Frykman O, Rohdin C, Leijon A, Soerensen KE, Järnegren J, Johnson GC, O'Brien DP, Granger N.
J Vet Intern Med. 2016 Sep;30(5):1681-1689.

Canine olfactory ensheathing cells from the olfactory mucosa can be engineered to produce active chondroitinase ABC.
Carwardine D, Fong-Wong L, Fawcett JW, Muir EM, Granger N
J Neurol Sci. 2016, 367:311-318.

A mutation in the Warburg syndrome gene, RAB3GAP1, causes a similar syndrome with polyneuropathy and neuronal vacuolation in Black Russian Terrier dogs.
Mhlanga-Mutangadura T, Johnson GS, Schnabel RD, Taylor JF, Johnson GC, Katz ML, Shelton GD, Lever TE, Giuliano E, Granger N, Shomper J, O'Brien DP.
Neurobiol Dis. 2016, 86:75-85.

What is your diagnosis? Acute non-weight bearing pelvic limb lameness in a dog.
Ievins A, Langley-Hobbs S, Barberet V, Granger N
Vet Comp Ortho and Trauma. 2016, 29(3):265-7.

Factors associated with recovery from paraplegia in dogs with loss of pain perception in the pelvic limbs following intervertebral disk herniation.
Jeffery ND, Barker AK, Hu HZ, Alcott CJ, Kraus KH, Scanlin EM, Granger N, Levine JM.
J Am Vet Med Assoc. 2016, 248(4):386-94.

Medical management of spinal epidural empyema in five dogs.
Monforte Monteiro SR, Gallucci A, Rousset N, Freeman P, Ives E, Gandini G, Granger N, Vanhaesebrouck A.
J Am Vet Med Assoc. 2016 Nov 15;249(10):1180-1186.

What Is Your Diagnosis? Diskospondylitis.
Hill MF, Warren-Smith C, Granger N.
J Am Vet Med Assoc. 2015, 247(7):743-5.

Prevalence of Chiari-like Malformations in Clinically Unaffected Dogs.
Harcourt-Brown TR, Campbell J, Warren-Smith C, Jeffery ND, Granger N.
J Vet Intern Med. 2015, 29(1):231-7.

Hypothalamic-anterior pituitary hormone deficiencies following traumatic brain injury in dogs.
Murtagh K, Arrol L, Goncalves R, Granger N, German AJ, Smith PM.
Vet Rec. 2015, 176(1):20.

Cell therapy for spinal cord injury – what’s really going on?
Granger N, Franklin RJ, Jeffery ND.
The Neuroscientist. 2014, 20(6):623-38.

Demyelinating polyneuropathy with focally folded myelin sheaths in a family of Miniature Schnauzer dogs.
Vanhaesebrouck AE, Couturier J, Cauzinille L, Mizisin AP, Shelton GD, Granger N.
J Neurol Sci. 2008 Dec 15;275(1-2):100-5.

What is your neurologic diagnosis? Fibrocartilaginous embolism in a cat.
Barker EN, Schofield E, Granger N
J Am Vet Med Assoc. 2014, 245(1):49-51.

The Impact of Demographic, Social, and Environmental Factors on the Development of Steroid-Responsive Meningitis-Arteritis (SRMA) in the United Kingdom.
Rose JH, Kwiatkowska M, Henderson ER, Granger N, Murray JK, Harcourt-Brown TR.
J Vet Intern Med. 2014, 28(4):1199-202.

Time requirement and effect on owners of home-based management of dogs with severe chronic spinal cord injury.
Freeman P M, Holmes MA, Jeffery ND, Granger N.
J Vet Behav. 2013, 8(6):439-43.

Use of an implanted sacral nerve stimulator to restore urine voiding in chronically paraplegic dogs.
Granger N, Chew D, Fairhurst P, Fawcett JW, Lacour SP, Craggs M, Mosse CA, Donaldson N, Jeffery ND.
J Vet Intern Med. 2013, 27(1):99-105.

Abnormal reflex activation of hamstring muscles in dogs with cranial cruciate ligament rupture.
Hayes GM, Granger N, Langley-Hobbs SJ, Jeffery ND.
Vet J. 2013 Jun;196(3):345-50.

Autologous olfactory mucosal cell transplants in clinical spinal cord injury: a randomized double-blinded trial in a canine translational model.
Granger N, Blamires H, Franklin RJ, Jeffery ND.
Brain. 2012 Nov;135(Pt 11):3227-37.

Effects of essential fatty acid supplementation in dogs with idiopathic epilepsy: A clinical trial.
Matthews H, Granger N, Wood J, Skelly B.
Vet J. 2012 Mar;191(3):396-8.

Designing clinical trials in canine spinal cord injury as a model to translate successful laboratory interventions into clinical practice.
Jeffery ND, Hamilton L, Granger N.
Vet Rec. 2011, 168(4):102-7.

Magnetic nanoparticle-mediated gene transfer to oligodendrocyte precursor cell transplant populations is enhanced by magnetofection strategies.
Jenkins SI, Pickard MR, Granger N, Chari DM.
ACS Nano. 2011, 5(8):6527-38.

A novel movement disorder in related male Labrador retrievers characterized by extreme generalized muscular stiffness.
Vanhaesebrouck AE, Shelton GD, Garosi L, Harcourt-Brown TR, Couturier J, Behr S, Harvey RJ, Jeffery ND, Matiasek K, Blakemore WF, Granger N.
J Vet Intern Med. 2011 Sep;25(5):1089-96.

Effects of syringomyelia on electrodiagnostic test results in Cavalier King Charles Spaniels.
Harcourt-Brown TR, Belshaw Z, Parker JE, Jeffery ND, Granger N.
Am J Vet Res. 2011, 72(5):595-600.

Effect of middle ear effusion on the brain-stem auditory evoked response of Cavalier King Charles Spaniels.
Harcourt-Brown TR, Parker JE, Granger N, Jeffery ND.
Vet J. 2011 Jun;188(3):341-5.

Canine inherited motor and sensory neuropathies: an updated classification in 22 breeds and comparison to Charcot-Marie-Tooth disease.
Granger N.
Vet J. 2011 Jun;188(3):274-85. Epub 2010 Jul 16. Review.

Clinical findings and treatment of non-infectious meningoencephalomyelitis in dogs: a systematic review of 457 published cases from 1962 to 2008.
Granger N, Smith PM, Jeffery ND.
Vet J. 2010 Jun;184(3):290-7. Epub 2009 May 1.

Comparison of two regimens for the treatment of meningoencephalomyelitis of unknown etiology.
Smith PM, Stalin CE, Shaw D, Granger N, Jeffery ND.
J Vet Intern Med. 2009 May-Jun;23(3):520-6.

Use of a lateral surgical approach to the femoral nerve in the management of two primary femoral nerve sheath tumours.
Harcourt-Brown TR, Granger N, Smith PM, Hughes K, Jeffery ND.
Vet Comp Orthop Traumatol. 2009;22(3):229-32.

Electrophysiologic evidence of polyneuropathy in a cat with signs of bilateral brachial plexus neuropathy.
Freeman PM, Harcourt-Brown TR, Jeffery ND, Granger N.
J Am Vet Med Assoc. 2009 Jan 15;234(2):240-4.

Clinical diagnosis and treatment of suspected neuropathic pain in three dogs.
Cashmore RG, Harcourt-Brown TR, Freeman PM, Jeffery ND, Granger N.
Aust Vet J. 2009 Jan-Feb;87(1):45-50.

Idiopathic polyradiculoneuropathy in a Bengal cat: electrophysiological findings and 1-year follow-up.
Granger N, Stalin CE, Brown TB, Jeffery ND.
J Feline Med Surg. 2008 Dec;10(6):603-7. Epub 2008 Jun 13.

Cerebellar vascular hamartoma in a British Shorthair cat.
Stalin CE, Granger N, Jeffery ND.
J Feline Med Surg. 2008 Apr;10(2):206-11. Epub 2008 Feb 20.

Radiographic morphology of the cranial portion of the cervical vertebral column in Cavalier King Charles Spaniels and its relationship to syringomyelia.
Stalin CE, Rusbridge C, Granger N, Jeffery ND.
Am J Vet Res. 2008 Jan;69(1):89-93.

Diagnosis and surgical removal of brain abscesses in a juvenile alpaca.
Talbot CE, Mueller K, Granger N, Jeffery ND.
J Am Vet Med Assoc. 2007 Nov 15;231(10):1558-61.

Magnetic resonance imaging in companion animal neurology.
Granger N.
Irish Veterinary Journal. 2007, 60(10):610-619.

Successful treatment of cervical spinal epidural empyema secondary to grass awn migration in a cat.
Granger N, Hidalgo A, Leperlier D, Gnirs K, Thibaud JL, Delisle F, Blot S.
J Feline Med Surg. 2007 Aug;9(4):340-5. Epub 2007 Apr 20.


Mesoangioblast stem cells ameliorate muscle function in dystrophic dogs.
Sampaolesi M, Blot S, D'Antona G, Granger N, Tonlorenzi R, Innocenzi A, Mognol P, Thibaud JL, Galvez BG, Barthélémy I, Perani L, Mantero S, Guttinger M, Pansarasa O, Rinaldi C, Cusella De Angelis MG, Torrente Y, Bordignon C, Bottinelli R, Cossu G.
Nature. 2006 Nov 30;444(7119):574-9.

Cutaneous saphenous nerve graft for the treatment of sciatic neurotmesis in a dog.
Granger N, Moissonnier P, Fanchon L, Hidalgo A, Gnirs K, Blot S.
J Am Vet Med Assoc. 2006 Jul 1;229(1):82-6.

Tissue Doppler imaging for detection of radial and longitudinal myocardial dysfunction in a family of cats affected by dystrophin-deficient hypertrophic muscular dystrophy.
Chetboul V, Blot S, Sampedrano CC, Thibaud JL, Granger N, Tissier R, Bruneval P, Gaschen F, Gouni V, Nicolle AP, Pouchelon JL.
J Vet Intern Med. 2006 May-Jun;20(3):640-7.

Plasma pro-opiomelanocortin, pro-adrenocorticotropin hormone, and pituitary adenoma size in dogs with Cushing's disease.
Granger N, de Fornel P, Devauchelle P, Segond S, Delisle F, Rosenberg D.
J Vet Intern Med. 2005 Jan-Feb;19(1):23-8.

Book chapters

BSAVA Manual of Canine and Feline Neurology, 4th edition, 2012, Edited by: Simon Platt and Natasha Olby, Chapter 9: Jeffery ND, Granger N.

Animal Models of Spinal Cord Repair (Neuromethods), 2012, Håkan Aldskogius (Editor), Human press; The canine spontaneous model of spinal cord injury; Jeffery ND, Granger N, Franklin RJF.

Acute spinal cord injury: tetraplegia and paraplegia in small animals.
Granger N, Carwardine D.
Vet Clin North Am Small Anim Pract. 2014, 44(6):1131-56.